There are 121 train lines in Tokyo. Yamanote line is the most famous because it loops through so many interesting neighborhoods. There are 29 neighborhoods on Yamanote line:
1. Shinagawa (品川)Shinagawa is a large business district that's filled with izakaya. It's a favorite salary man party town.
2. Osaki (大崎)Osaki is a bland business district filled with business parks and manshons that look like the suburbs.
3. Gotanda (五反田)Gotanda is similar to Shinagawa — it's a large business and entertainment district.
4. Meguro (目黒)Meguro is a chill dining and shopping district. It's also one of Tokyo's best residential neighborhoods.
5. Ebisu (恵比寿)Ebisu is an upscale business, residential and entertainment area.
6. Shibuya (渋谷)Shibuya is a massive youth-oriented entertainment and shopping district.
7. Harajuku (原宿)Harajuku is a shopping area that's well known for its Japanese street fashions and cosplay.
8. Yoyogi (代々木)Yoyogi is an artsy residential neighborhood best known for its wild park.
9. Shinjuku (新宿)Shinjuku station is the busiest train station in the world. It's a massive business, dining, shopping and entertainment neighborhood. Shinjuku is also home to the largest red light district in Japan.
10. Shin-Okubo (新大久保)Shin-Okubo is Tokyo's Korea town.
11. Takadanobaba (高田馬場)Takadanobaba is a college neighborhood that's home to Waseda University.
12. Mejiro (目白)Mejiro is one of the smallest neighborhoods on the Yamanote line. It's a rare station with only one exit. Mejiro is a residential district that's best known as the home of Gakushuin University. Much of the Emperor's family (Japan's Imperial Family) attended Gakushuin University. It's a elite private university.
13. Ikebukuro (池袋)Ikebukuro is Tokyo's second busiest station serving 2.71 million passengers per day. It's a shopping area where Japan's retail titans are locked in a battle for customers.
14. Otsuka (大塚)Otsuka is a sleepy residential district on the outskirts of Ikebukuro.
15. Sugamo (巣鴨)Sugamo is what Tokyo would be like if everyone was a senior citizen.
16. Komagome (駒込)Komagome is a quiet residential district. It's home to Rikugien — a large Edo-era Japanese strolling garden. The garden reproduces 88 scenes from well known classical poems.
17. Tabata (田端)Tabata is an old residential district.
18. Nishi-Nippori (西日暮里)Nishi-Nippori is a small residential neighborhood that's essentially part of Nippori (below).
19. Nippori (日暮里)Nippori is an old merchant district of Tokyo that's filled with street markets, temples, shrines and old houses. It's also known for its large old cemetery that inters Japan's last Shogun.
20. Uguisudani (鶯谷)Uguisudani sits at the northeast side of Ueno Park. It's home to the Tokyo University of the Arts.
21. Ueno (上野)Ueno is best known for its large park that's filled with attractions, museums and cultural institutions.
22. Okachimachi (御徒町)A busy commercial area known for Ameyoko (candy shop alley) — a chaotic shopping bazaar.
23. Akihabara (秋葉原)Akihabara is what Tokyo would be like if everyone was a nerd (otaku).
24. Kanda (神田)Kanda is an old business district known for its large sports and book shopping districts.
25. Tokyo (東京)Tokyo Station is the city's main shinkansen hub that connects Tokyo with the rest of Japan. The surrounding area (e.g. Marunouchi) is a massive business and entertainment district.
26. Yurakucho (有楽町)Yurakucho is an extension of the large business district around Tokyo station. It's best known for its charming restaurants under the tracks of the Yamanote line.
27. Shimbashi (新橋)Shimbashi is another salary man paradise and business district.
28. Hamamatsucho (浜松町)Hamamatsucho is a business district on Tokyo's waterfront. The area has spectacular views of Tokyo Bay and Odaiba.
29. Tamachi (田町)Tamachi is a business district that's also home to several colleges (e.g. Tokyo International School). The mix of salary men and students in the area makes for some interesting nightlife (mostly izakaya).